When looking at stem cells I do not see any issue with research and discovery of the human form and how it works and adapts to various environments. When doing some research in electrophysiology and osteon remodeling it was interesting to find that stem cells traditionally hold a neutral position while the daughter cells of differentiation have polar moments. When looking at osteoclasts and osteoblasts during osteon development, there is a finding under Wolff's law that the distribution of new and old bone does so along lines of tension and pressure: osteoclasts dissolve bone, osteoblasts develop new bone. It was found that carpenters that underwent anatomical dissection had a greater density of bone on their hammering hand that was significant when compared to individuals that did not undergo the recoil and reverberation in their bones with less intense occupations. When looking at research that uses polarization therapy on osteoblast and osteoclasts Kumar et al found that neutral development was significantly less than conditions with a positive charge when looking at osteoblast development and the contrary for osteoclast development. When looking at this there is a premise that neutral cells are "stem" cells and then the polarization of the environment will influence the proliferation of differential cell lines. In studying polarization therapy researchers have looked at how polar moments in differentiating cell lines impact development and it was found that cells that divide asymmetrically, even along the slightest axis, will take on different cell lines and it is in the regions of separation and not the amount in each individual daughter cell that has this impact. This makes sense in the development where cells in a stable neutral environment well multiply with ease and under the right conditions produce the exact copies they need. Being human gives us the ultimate ability to adapt and this is shown. The body naturally begins to respond to the extra cellular matrix and this modeling impacts the cell lines and overall rate and continuity of development. As the conditions change and ions change the cells that divide do so in a manner to maintain homeostasis to keep an overall neutral environment, as expressed by Kumar et al. They talk about the parallel and perpendicular orientation of mitotic spindles during division and how this changes the fate of the cell line. When looking at this it would make sense that there are times where a cellular shift or break in the 3D structure and chain, depending on which nervous system theory you follow, would sendoff dividing cells with a different pull on them based on the new micro environment and changes in the ECM. Toledano and Jones spoke to this where the protein structures and changes in cellular polarity give rise to and influence the asymmetrical development of daughter cells and therefore new proliferating cell lines.
With osteon development research in carpenters and woodsmen and Wolffs law showing the shifts and changes of cellular signaling to generate osteoblast and osteoclast influences on an osteon cell line, some interesting research can be planned and used on types of stem cells that do not need to be glorified and turned into human research projects to fight natures way of developing us. These pressures and understanding of how use and reuse after injury and remodeling under lines of tension and use in both bone and skin cells makes energy and magnetic or electric stimulation a common use to restore skin scars or activating and using muscles and putting stress on bones again after injury is the most effective way of restoring use and healing. Wonder why stem cell transplants aren’t successful, I would say they aren’t giving the new cell the signaling to adapt to the natural environment if they just plop it there and don’t stimulate the pathways that it lies in. When those big breaks happen and outward injury is apparent we see how the body gives to nature’s pressure. We don’t realize that all of the little breaks and changes in the polarity of our diving cells during daily life can change where they go to after they are stimulated by a break or injury that might be there to restore homeostasis as spoke to in the articles. These are our “stem cells” Now imagine all of the other things that we go though on a level of polarity changes in the body to change cell lines. There are cases where people who survive radiation therapy for bone cancer and then die from leukemia, the resounding vibrations on a level at the microenvironment over red marrow change blood cell development too. Neuronal cells, are shown to thicken in a linear fashion after an electrical moment is passed over them as well as expressed in individuals that study neurological comparisons for electrical properties of conductors and insulators in circuitry as shown by Carpintero et al.
Stem cell research could really be used to promote some older beliefs in energetic medicine and techniques of reflexology where you “strum” the nervous system to get certain reverberations. Ancient forms of medicine such as acupuncture, reflexology and herbology frequently stand on a premise that stimulating this energetic system would restore and change the currents in the body for healing. This could potentially impact the polar moments that keep more neutral stem cells developing as well. It I can be understood along the lines of cells developing inside a framework of energy like a spiders web, spoken to in the reticular theory of understanding neuronal networking. The activity of energy lines that create cells within to drop out of would explain some of the meshwork regions in the muscular system that will remodel and restore under lines of use and tension, this could be an adaptive strategy in human development as destroying and nullifying waste to create a new cell would be much more costly to the system. Then according to other theories of use and disuse spoken to under Wolffs Law, this energy imacts developing cells to the alter the pressures below. This would then generate a cascade of communication between more cells or another protein structure and framework of cellular reactions in a microenvironment. Ok there . . stem cells.
Photo Source & Additional Reading here
E. Moreno Carpintero2, J. M. Malo1, J. Uruchurtu Chavarin2, J. A. Hernández 2 Simulation of the Corrosion Behavior of Electric Transmission Lines Tower Legs By Means of Neural Networks. 1 Instituto de Investigaciones Electricas, Av. Palmira, Cuernavaca, Morelos, México, IIE. 2 Unicersidad Autonoma del Estado de Morelos, CIICAp, Av. Universidad 1001, Col. Chamilpa C.P. 62209 Cuernavaca, Morelos, México.
D. Kumar a, J.P. Gittings b, I.G. Turner b,*, C.R. Bowen b, A. Bastida-Hidalgo a, S.H. Cartmell Polarization of hydroxyapatite: Influence on osteoblast cell proliferation
Institute of Science and Technology in Medicine, University of Keele, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire ST4 7QB, UK . Centre for Orthopaedic Biomechanics, Department of Mechanical Engineering, University of Bath, Bath BA2 7AY, UK
Hila Toledano, D. Leanne Jones,. Mechanisms regulating stem cell polarity and the specification of asymmetric divisions . Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037
R.A. Walker, C.O. Lovejoy and R. Cordes. Histomorphological Variation in the Appendicular Skeleton . Department of Clinical Anatomy, New York Chiropractic College and Dept. of Anthropology and Division of Biomedical Sciences, Kent State University, USA